Better Safe than Sorry: A Dual-Function Viral Protein Inhibiting Host Defense

Cell Host Microbe. 2018 Oct 10;24(4):467-469. doi: 10.1016/j.chom.2018.09.012.

Abstract

Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Argonaute Proteins / immunology*
  • Dicistroviridae / immunology
  • Drosophila Proteins / immunology*
  • Drosophila melanogaster
  • Host-Pathogen Interactions / immunology*
  • Immunity, Innate
  • RNA Interference
  • Viral Proteins / immunology*

Substances

  • AGO2 protein, Drosophila
  • AGO2 protein, human
  • Argonaute Proteins
  • Drosophila Proteins
  • Viral Proteins

Supplementary concepts

  • Cricket paralysis virus