Abstract
Viruses employ intricate means to evade host innate immune systems. In this issue of Cell Host & Microbe, Nayak et al. (2018) demonstrate that the cricket paralysis virus (CrPV) protein CrPV-1A blocks host defense through a dual mechanism: directly inhibiting Argonaute2 (Ago2) and simultaneously targeting Ago2 for proteasomal degradation.
Copyright © 2018 Elsevier Inc. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Argonaute Proteins / immunology*
-
Dicistroviridae / immunology
-
Drosophila Proteins / immunology*
-
Drosophila melanogaster
-
Host-Pathogen Interactions / immunology*
-
Immunity, Innate
-
RNA Interference
-
Viral Proteins / immunology*
Substances
-
AGO2 protein, Drosophila
-
AGO2 protein, human
-
Argonaute Proteins
-
Drosophila Proteins
-
Viral Proteins