Open Sesame: New Keys to Unlocking the Gate to Norovirus Infection

Marit Lingemann; Stefan Taube

doi:10.1016/j.chom.2018.09.018

Open Sesame: New Keys to Unlocking the Gate to Norovirus Infection

Cell Host Microbe. 2018 Oct 10;24(4):463-465. doi: 10.1016/j.chom.2018.09.018.

Authors

Marit Lingemann¹, Stefan Taube²

Affiliations

¹ Institute of Virology and Cell Biology, University of Luebeck, Luebeck, Germany.
² Institute of Virology and Cell Biology, University of Luebeck, Luebeck, Germany. Electronic address: stefan.taube@uni-luebeck.de.

PMID: 30308149
DOI: 10.1016/j.chom.2018.09.018

Abstract

Three recent papers highlight the impact of an entry receptor on murine norovirus pathogenesis. CD300lf was shown to be the first proteinaceous entry receptor for a norovirus, specialized intestinal epithelial cells constitute the reservoir for persistence, and a new link between the receptor and a lipid biosynthetic enzyme was revealed.

MeSH terms

Animals
Caliciviridae Infections / virology*
Epithelial Cells / virology
Intestines / virology
Mice
Norovirus*
Sesamum*