A Sugar Rush for Innate Immunity

Cell Host Microbe. 2018 Oct 10;24(4):461-463. doi: 10.1016/j.chom.2018.09.017.

Abstract

Early detection of microbial patterns is a hallmark of innate immunity and essential for clearance of invading pathogens. A recent Nature publication by Zhou et al. (2018) has uncovered ALPK1 as a pattern recognition receptor for Gram-negative bacteria triggering NF-κB activation and identified the bacterial sugar ADP-Hep as its ligand.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carrier Proteins
  • Gram-Negative Bacteria / metabolism
  • Host-Pathogen Interactions / immunology
  • Immunity, Innate / immunology*
  • Inflammation
  • Mice
  • Mice, Knockout
  • NF-kappa B / metabolism
  • Protein Kinases / genetics
  • Protein Kinases / immunology*
  • Receptors, Pattern Recognition / immunology*
  • Signal Transduction / physiology
  • Sugars / immunology*
  • Type III Secretion Systems

Substances

  • Carrier Proteins
  • NF-kappa B
  • Receptors, Pattern Recognition
  • Sugars
  • Type III Secretion Systems
  • ALPK1 protein, mouse
  • Protein Kinases