The In Situ Sulfidation of Cu2 O by Endogenous H2 S for Colon Cancer Theranostics

Angew Chem Int Ed Engl. 2018 Nov 26;57(48):15782-15786. doi: 10.1002/anie.201810082. Epub 2018 Nov 7.

Abstract

Expression of a high concentration of H2 S is closely related to the formation of colon cancer tumors. However, only a few H2 S-triggered theranostics agents for colon cancer have been reported to date. Now, a turn-on theranostics agent was developed by utilizing the in situ reaction of Cu2 O and endogenous H2 S at colon tumor sites. Based on in vitro and in vivo experiments, excellent photoacoustic imaging and photothermal therapy were both confirmed by this in situ reaction-activated colon cancer theranostics method. This work established a simple and efficient strategy for both diagnosis and treatment of colon cancer with a novel trigger mechanism, which provides a new route for colon cancer theranostics based on the in situ reactions at the tumor sites.

Keywords: colon cancer; cuprous oxide; endogenous H2S; in situ reactions; theranostics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Proliferation / drug effects
  • Colonic Neoplasms / diagnostic imaging
  • Colonic Neoplasms / drug therapy*
  • Copper / chemistry
  • Copper / pharmacology*
  • HCT116 Cells
  • Humans
  • Hydrogen Sulfide / chemistry
  • Hydrogen Sulfide / pharmacology*
  • Mice
  • Nanoparticles / chemistry
  • Neoplasms, Experimental / diagnostic imaging
  • Neoplasms, Experimental / drug therapy
  • Particle Size
  • Photoacoustic Techniques
  • Photochemotherapy
  • Sulfides / chemistry
  • Sulfides / pharmacology*
  • Theranostic Nanomedicine*

Substances

  • Antineoplastic Agents
  • Sulfides
  • Copper
  • cuprous oxide
  • Hydrogen Sulfide