Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti⁻Inflammatory Activities

Molecules. 2018 Oct 9;23(10):2577. doi: 10.3390/molecules23102577.

Abstract

One new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4⁻7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic data, especially 2D NMR data and comparison with literatures. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production in vitro. Compounds 3 and 7 exhibited moderate inhibitory effects on NO production with IC50 values of 12.2 ± 0.8 and 18.9 ± 0.3 μM, respectively.

Keywords: Scindapsus officinalis; anti-inflammatory activity; caffeoyl derivative; monoterpene glycoside; phenyl glycoside.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology
  • Araceae / chemistry*
  • Cell Survival / drug effects
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Nitric Oxide / biosynthesis
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • RAW 264.7 Cells

Substances

  • Anti-Inflammatory Agents
  • Plant Extracts
  • Nitric Oxide