Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates

Yuwen Yang; Weibo Yang

doi:10.1039/c8cc06945j

Divergent synthesis of N-heterocycles by Pd-catalyzed controllable cyclization of vinylethylene carbonates

Chem Commun (Camb). 2018 Oct 25;54(86):12182-12185. doi: 10.1039/c8cc06945j.

Authors

Yuwen Yang¹, Weibo Yang

Affiliation

¹ Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

PMID: 30302489
DOI: 10.1039/c8cc06945j

Abstract

Here, we report a palladium-catalyzed controllable cyclization of vinyl ethylene carbonates that proceeds through formal migration [2+3] and [5+2] cycloadditions, respectively, under mild conditions. The transformation described here affords a series of synthetically versatile 5,7-membered N-heterocycles which are found in natural products and pharmaceuticals with biological and medicinal properties.