Background: The aim of this study was to investigate the effect of early diagnosis in children with Green-Barre Syndrome (GBS) via joint detection of biochemical markers and electrophysiological examination.
Methods: A total of 90 children with (GBS collected from the Department of Neurology, Intensive Care Unit (ICU), Rehabilitation Department of Cerebral Palsy of Children's Hospital Affiliated to Zhengzhou University, Department of Pediatrics of First Affiliated Hospital of Zhengzhou University and Henan Province People's Hospital were selected as the research objects. According to their onset time, they were divided into group A (N.=30) hospitalized within 3 days of onset, group B (N.=30) hospitalized from 4 to 7 days of onset, and group C (N.=30) hospitalized after more than 7 days of onset. The titer levels of serum anti-ganglioside immunoglobulin G (IgG) antibodies, the motor nerve conduction velocity (MCV), Hoffmann reflex (H-reflex) condition and serum immunoglobulin in all groups of children were compared.
Results: The levels of serum anti-ganglioside IgG antibodies in three groups of children from low to high were group A<group B<group C. MCV decreasing rates in group A, B and C were successively 3.33%, 16.66% and 29.99%, namely group A<group B<group C. 60 cases of H-reflex were detected in each group, and the abnormal rates were successively 76.66%, 81.66% and 95% respectively in group A, group B and group C, namely group A<group B<group C. The serum levels of immunoglobulin in three groups of children from low to high were group A<group B<group C (P<0.05).
Conclusions: Anti-ganglioside antibody, electrophysiological parameter and serum level of immunoglobulin can be helpful in the diagnosis of GBS, and the changes in them can be monitored clinically so as to carry out the early treatment effectively for children and improve the prognosis.