tsRNAs: The Swiss Army Knife for Translational Regulation

Junchao Shi; Yunfang Zhang; Tong Zhou; Qi Chen

doi:10.1016/j.tibs.2018.09.007

tsRNAs: The Swiss Army Knife for Translational Regulation

Trends Biochem Sci. 2019 Mar;44(3):185-189. doi: 10.1016/j.tibs.2018.09.007. Epub 2018 Oct 5.

Authors

Junchao Shi¹, Yunfang Zhang², Tong Zhou³, Qi Chen⁴

Affiliations

¹ Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA; These authors contributed equally.
² Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA; Research Center of Department of Hematology, Xinqiao Hospital, Army Medical University, Chongqing 40037, China; These authors contributed equally.
³ Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA. Electronic address: tongz@med.unr.edu.
⁴ Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA. Electronic address: cqi@med.unr.edu.

Abstract

tRNA-derived small RNAs (tsRNAs, or tRFs) are a new category of regulatory noncoding RNAs with versatile functions. Recent emerging studies have begun to unveil distinct features of tsRNAs based on their sequence, RNA modifications, and structures that differentially impact their functions towards regulating multiple aspects of translational control and ribosome biogenesis.

Keywords: RNA modification; RNA structure; ribosome; tRNA-derived small RNA; translational regulation.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Humans
Proteomics
RNA, Small Untranslated / genetics
RNA, Small Untranslated / metabolism*
RNA, Transfer / genetics
RNA, Transfer / metabolism*

Substances

RNA, Small Untranslated
RNA, Transfer

Grants and funding

R01 HD092431/HD/NICHD NIH HHS/United States