Advanced imaging modalities to detect cardiotoxicity

Curr Probl Cancer. 2018 Jul;42(4):386-396. doi: 10.1016/j.currproblcancer.2018.05.005. Epub 2018 Jun 11.

Abstract

Recent advances in cancer treatments have significantly improved survival rates, reemphasizing the focus on reducing the potential complications associated with some therapies. Cardiovascular disease associated with chemotherapies is a major cause of morbidity and mortality in cancer survivors. Early detection of cardiotoxicity improves cardiac outcomes among cancer patients. The review will focus on imaging modalities used to assess cardiotoxicity - the cardiovascular consequences of chemotherapies. The review will discuss the benefits and limitations associated with each technique, as well as the guidelines available to help identify at risk patients. We will discuss novel techniques that may help detect earlier signs of cardiotoxicity, directing management that may improve clinical outcomes.

Keywords: Cardiac magnetic resonance; Cardiotoxicity; Chemotherapy; Computed tomography; Echocardiography; Ejection fraction; Radionuclide imaging.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Cardiac Imaging Techniques / methods*
  • Cardiotoxicity / diagnosis*
  • Cardiotoxicity / diagnostic imaging*
  • Cardiotoxicity / etiology
  • Humans
  • Neoplasms / drug therapy*
  • Prognosis
  • Risk Factors

Substances

  • Antineoplastic Agents