Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection

Liyana Ahmad; Bayarchimeg Mashbat; Corwin Leung; Charlotte Brookes; Samar Hamad; Sina Krokowski; Avinash R Shenoy; Lazaro Lorenzo; Michael Levin; Peter O'Hare; Shen-Ying Zhang; Jean-Laurent Casanova; Serge Mostowy; Vanessa Sancho-Shimizu

doi:10.1016/j.jaci.2018.09.013

Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection

J Allergy Clin Immunol. 2019 Feb;143(2):765-769.e7. doi: 10.1016/j.jaci.2018.09.013. Epub 2018 Oct 5.

Affiliations

¹ Department of Virology, Division of Medicine, Imperial College London, London, United Kingdom.
² Department of Paediatrics, Division of Medicine, Imperial College London, London, United Kingdom.
³ MRC Centre of Molecular Bacteriology and Infection (CMBI), Imperial College London, London, United Kingdom; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
⁴ Section of Microbiology, MRC CMBI, Imperial College London, London, United Kingdom.
⁵ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Descartes, Imagine Institute, Paris, France.
⁶ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Descartes, Imagine Institute, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY.
⁷ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Descartes, Imagine Institute, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY; Howard Hughes Medical Institute, New York, NY; Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, Paris, France.
⁸ Department of Virology, Division of Medicine, Imperial College London, London, United Kingdom; Department of Paediatrics, Division of Medicine, Imperial College London, London, United Kingdom. Electronic address: v.sancho-shimizu@imperial.ac.uk.

PMID: 30296527
DOI: 10.1016/j.jaci.2018.09.013

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Vesicular Transport / genetics*
Adaptor Proteins, Vesicular Transport / metabolism
Autophagy / genetics
Cells, Cultured
Child
Encephalitis, Herpes Simplex / metabolism*
Fibroblasts / physiology*
Herpesvirus 1, Human / physiology*
Humans
Interferon Regulatory Factor-3 / metabolism
Interferons / metabolism
Microtubule-Associated Proteins / genetics
Microtubule-Associated Proteins / metabolism
Mutation / genetics*
Poly I-C / immunology
Protein Serine-Threonine Kinases / genetics*
Protein Serine-Threonine Kinases / metabolism
RNA, Small Interfering / genetics
Signal Transduction
Toll-Like Receptor 3 / metabolism*

Substances

Adaptor Proteins, Vesicular Transport
IRF3 protein, human
Interferon Regulatory Factor-3
MAP1LC3B protein, human
Microtubule-Associated Proteins
RNA, Small Interfering
TICAM1 protein, human
TLR3 protein, human
Toll-Like Receptor 3
Interferons
Protein Serine-Threonine Kinases
TBK1 protein, human
Poly I-C

Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection

Authors

Affiliations

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MeSH terms

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