Objective: To explore the hematological and clinical features of patients with malignant lymphoma (ML) combined with venous thromboembolism (VTE).
Methods: Sixty patients with ML combined with VTE in our hospital from May 2014 to May 2016 were enrolled in ML+VTE group, out of them 42 patients were males and 18 patients with females; another 60 patients with ML alone were enrolled in control group, out of them 43 patients were males and 17 patients females. The hematological, coagulation and clinical datas of all the patients were collected and then retrospectively analyzed.
Results: About 81.54% of the patients in ML+VTE group were found in Stage ⅢB-Ⅳ tumor, and about 66.67% patients were found after ML was diagnosed; about 85.00% were with deep vein thrombosis (DVT), 10.00% were with pulmonary embolism (PE), and 5.00% were complicated with both DVT and PE. Common DVT locations in 56.67% cases were the upper limb and the neck vein(56.67%); The total effective rate of the cases with DVT was 49.02%, and the rate of cases with PE was 14.29%, and 0 in the cases with both DVT and PE, the difference was statistically significant (χ2=72.650, P<0.001). Compared with the patients of control group, the levels of platelet aggregation, D-dimer, high cut blood viscosity, low cut blood viscosity, plasma viscosity, hematocrit, assembly index of erythrocyte, and rigidity index of erythrocyte were higher in patients of ML+VTE group (P<0.05), and APTT, erythrocy tesed imentation rate, deformability index of erythrocyte, and average velocity of blood flow were reduced, the differences were statistically significant (P<0.05).
Conclusion: Hemaorheology and coagulation of patients with ML combined with VTE indicate changes in the sensitivity state of thromboembolism; DVT, which is commonly manifested in the upper limb and the neck vein, and it mainly observed in patients with end-stage.