Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity

Yasushi Kishimoto; Ikuko Tsukamoto; Atsuko Nishigawa; Akiko Nishimoto; Yutaka Kirino; Yoshihisa Kato; Ryoji Konishi; Tokumi Maruyama; Norikazu Sakakibara

doi:10.1016/j.dib.2018.09.044

Data on COA-Cl administration to the APP/PS2 double-transgenic mouse model of Alzheimer׳s disease: Improved hippocampus-dependent learning and unchanged spontaneous physical activity

Data Brief. 2018 Sep 19:20:1877-1883. doi: 10.1016/j.dib.2018.09.044. eCollection 2018 Oct.

Authors

Yasushi Kishimoto¹, Ikuko Tsukamoto², Atsuko Nishigawa¹, Akiko Nishimoto¹, Yutaka Kirino¹, Yoshihisa Kato¹, Ryoji Konishi², Tokumi Maruyama¹, Norikazu Sakakibara¹

Affiliations

¹ Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
² Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University, Japan.

Abstract

We herein present behavioral data regarding whether COA-Cl, a novel adenosine-like nucleic acid analog that promotes angiogenesis and features neuroprotective roles, improves cognitive and behavioral deficits in a murine model for Alzheimer׳s disease (AD). COA-Cl induced significant spatial memory improvement in the amyloid precursor protein/presenilin 2 double-transgenic mouse model of AD (PS2Tg2576 mice). Correspondingly, non-spatial novel object cognition test performance also significantly improved in COA-Cl-treated PS2Tg2576 mice; however, these mice demonstrated no significant changes in physical activity or motor performance. COA-Cl did not change the spontaneous activities and cognitive ability in the wild-type mice.

Keywords: AD, Alzheimer׳s disease; APP, amyloid precursor protein; Alzheimer׳s disease; Angiogenesis; MWM, Morris water maze; Non-spatial memory; Novel object cognition test; PS2, presenilin 2; Spatial memory; Spontaneous physical activity.