Phosphaturic mesenchymal tumor and related wound problem

Medicine (Baltimore). 2018 Oct;97(40):e12507. doi: 10.1097/MD.0000000000012507.

Abstract

Introduction: Phosphaturic mesenchymal tumor mixed connective tissue type (PMT/MCT) is the most common type (up to 90%) of phosphaturic mesenchymal tumor (PMT), a rare clinicopathologic entity. Besides overproduction of fibroblast growth factor 23 (FGF23), there is a big variation of immunohistochemical characteristic across types of PMT, which makes it difficult to obtain an early diagnosis of PMT/MCT. As a benign tumor, PMT/MCT usually happens in subcutaneous tissues and leads to nonhealing of wound. A complete excision of PMT/MCT facilitates wound healing.

Conclusions: Review of the existing evidence indicates that early diagnosis of PMT/MCT is critically important when treating PMT/MCT wound. Hence standardization of early diagnosis for PMT/MCT is mandated.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Biomarkers, Tumor / blood
  • Diagnosis, Differential
  • Early Detection of Cancer
  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / biosynthesis
  • Humans
  • Hypophosphatemia, Familial / blood
  • Hypophosphatemia, Familial / diagnosis*
  • Hypophosphatemia, Familial / etiology
  • Mesenchymoma / blood
  • Mesenchymoma / diagnosis*
  • Mesenchymoma / etiology
  • Mixed Connective Tissue Disease / blood
  • Mixed Connective Tissue Disease / diagnosis*
  • Mixed Connective Tissue Disease / etiology
  • Soft Tissue Neoplasms / blood
  • Soft Tissue Neoplasms / diagnosis*
  • Soft Tissue Neoplasms / etiology
  • Wounds and Injuries / blood
  • Wounds and Injuries / complications*

Substances

  • Biomarkers, Tumor
  • FGF23 protein, human
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23