Abstract
In this issue of Blood, Arezes and colleagues present new and exciting evidence that erythropoietin (EPO) suppresses bone morphogenetic protein (BMP)-mediated signaling in an erythroferrone (ERFE)-dependent mechanism and ERFE in turn interferes with the binding of a specific set of BMPs to their receptors. These findings represent a breakthrough in the understanding of how EPO and ERFE function to decrease hepcidin expression.
MeSH terms
-
Hepcidins / antagonists & inhibitors
-
Hepcidins / metabolism*
-
Humans
-
Peptide Hormones*
Substances
-
Erfe protein, human
-
Hepcidins
-
Peptide Hormones