Virus Assembly Antagonists from Redesigned Antibodies

Zhongchao Zhao; Adam Zlotnick

doi:10.1016/j.str.2018.09.002

Virus Assembly Antagonists from Redesigned Antibodies

Structure. 2018 Oct 2;26(10):1297-1299. doi: 10.1016/j.str.2018.09.002.

Authors

Zhongchao Zhao¹, Adam Zlotnick²

Affiliations

¹ Department of Molecular and Cellular Biochemistry Indiana University, Bloomington, IN 47405, USA.
² Department of Molecular and Cellular Biochemistry Indiana University, Bloomington, IN 47405, USA. Electronic address: azlotnic@indiana.edu.

PMID: 30282016
DOI: 10.1016/j.str.2018.09.002

Abstract

There is no reliable cure for chronic Hepatitis B Virus (HBV). In this issue of Structure, Eren et al. (2018) show how antibody-derived proteins bind different forms of the HBV capsid protein, blocking assembly. This interaction may also affect downstream signaling. These antibody-derived molecules mark a new strategy that may ultimately contribute to a cure.

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MeSH terms

Antigen-Antibody Complex
Capsid
Capsid Proteins
Hepatitis B virus*
Virus Assembly*

Substances

Antigen-Antibody Complex
Capsid Proteins