In a review article analyzes and summarizes information on the current pathogenesis of bile peritonitis. The role of endothelial dysfunction markers, as a factor in the development of ischemic disorders interstitial circulation contributes to the elucidation of the molecular mechanisms of the pathogenesis of peritonitis, including bile peritonitis. This review is an attempt to synthesize and analyze accumulated information on the pathogenetic aspects of the development of peritonitis, which will optimize the diagnosis, the development of methods of prevention and treatment. This study dysfunction of vascular endothelium, will provide additional information relevant to the prediction of the adaptation of the organism in the syndrome of endogenous intoxication.