Blood-Based Prediction of Tumor Relapse: The cfDNA Forecast

Cancer Discov. 2018 Oct;8(10):1213-1215. doi: 10.1158/2159-8290.CD-18-0952.

Abstract

Khan and colleagues demonstrate how serial blood-based liquid biopsies integrated with imaging and mathematical modeling can accurately "forecast" the time to treatment failure in patients with metastatic colorectal cancer treated with EGFR blockade, by early detection of molecular alterations associated with drug resistance in cell-free DNA. Cancer Discov; 8(10); 1213-5. ©2018 AACR See related article by Khan et al., p. 1270.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell-Free Nucleic Acids*
  • Clonal Evolution
  • Colorectal Neoplasms*
  • Humans
  • Liquid Biopsy
  • Neoplasm Recurrence, Local
  • Time-to-Treatment

Substances

  • Cell-Free Nucleic Acids