Coronary fractional flow reserve derived from intravascular ultrasound imaging: Validation of a new computational method of fusion between anatomy and physiology

Abstract

Objectives: To evaluate the diagnostic performance of a novel computational algorithm based on three-dimensional intravascular ultrasound (IVUS) imaging in estimating fractional flow reserve (IVUS_FR ), compared to gold-standard invasive measurements (FFR_INVAS ).

Background: IVUS provides accurate anatomical evaluation of the lumen and vessel wall and has been validated as a useful tool to guide percutaneous coronary intervention. However, IVUS poorly represents the functional status (i.e., flow-related information) of the imaged vessel.

Methods: Patients with known or suspected stable coronary disease scheduled for elective cardiac catheterization underwent FFR_INVAS measurement and IVUS imaging in the same procedure to evaluate intermediate lesions. A processing methodology was applied on IVUS to generate a computational mesh condensing the geometric characteristics of the vessel. Computation of IVUS_FR was obtained from patient-level morphological definition of arterial districts and from territory-specific boundary conditions. FFR_INVAS measurements were dichotomized at the 0.80 threshold to define hemodynamically significant lesions.

Results: A total of 24 patients with 34 vessels were analyzed. IVUS_FR significantly correlated (r = 0.79; P < 0.001) and showed good agreement with FFR_INVAS , with a mean difference of -0.008 ± 0.067 (P = 0.47). IVUS_FR presented an overall accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of 91%, 89%, 92%, 80%, and 96%, respectively, to detect significant stenosis.

Conclusion: The computational processing of IVUS_FR is a new method that allows the evaluation of the functional significance of coronary stenosis in an accurate way, enriching the anatomical information of grayscale IVUS.

Keywords: computational fluid dynamics; coronary artery disease; coronary blood flow/physiology/microvascular function; fractional flow reserve; imaging intravascular ultrasound; interventional devices/innovation; quantitative coronary angiography; three-dimensional coronary models.