Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction of α-Diazoacetates and β-Trifluoromethyl Enones: A Facile Access to Multisubstituted 4-(Trifluoromethyl)pyrazolines

Yongfeng Li; Huamin Wang; Yuwei Su; Runchen Li; Cao Li; Lu Liu; Junliang Zhang

doi:10.1021/acs.orglett.8b02757

Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction of α-Diazoacetates and β-Trifluoromethyl Enones: A Facile Access to Multisubstituted 4-(Trifluoromethyl)pyrazolines

Org Lett. 2018 Oct 19;20(20):6444-6448. doi: 10.1021/acs.orglett.8b02757. Epub 2018 Oct 2.

Authors

Yongfeng Li¹, Huamin Wang¹, Yuwei Su¹, Runchen Li¹, Cao Li¹, Lu Liu¹, Junliang Zhang¹

Affiliation

¹ School of Chemistry and Molecular Engineering , East China Normal University , 500 Dongchuan Road , Shanghai 200241 , P. R. China.

PMID: 30277401
DOI: 10.1021/acs.orglett.8b02757

Abstract

A novel phosphine-catalyzed [3 + 2] cycloaddition of α-diazoacetates and β-trifluoromethyl enones has been developed that provides facile access to multisubstituted 4-(trifluoromethyl)pyrazolines in good to excellent yields at room temperature. In addition, a tandem [3 + 2] cycloaddition/Michael addition is also presented.

Publication types

Research Support, Non-U.S. Gov't