Abstract
We report here one case of Zika virus (ZIKV) infection associated with auto-immunity directed against the central nervous system in a Brazilian woman who developed acute transverse myelitis 9 days after recovery from an acute episode of fever with generalized erythema. Imaging of the spinal cord showed an elongated area on the T1-T10 level with gadolinium uptake. The diagnostic of the ZIKV infection was confirmed by cerebrospinal fluid and serum analysis. This patient had serum positivity for autoantibodies against myelin oligodendrocyte glycoprotein (MOG), a specific antibody against the myelin sheath. We propose that a direct central nervous system infection by ZIKV could lead to a specific auto-immunity against MOG protein.
MeSH terms
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Acute Disease
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Adult
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Autoantibodies / biosynthesis*
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Brazil
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Contrast Media / administration & dosage
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Erythema / complications
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Erythema / diagnostic imaging
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Erythema / immunology*
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Erythema / virology
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Female
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Gadolinium / administration & dosage
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Humans
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Magnetic Resonance Imaging
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Myelin Sheath / immunology
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Myelin Sheath / pathology
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Myelin Sheath / virology
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Myelin-Oligodendrocyte Glycoprotein / antagonists & inhibitors
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Myelin-Oligodendrocyte Glycoprotein / immunology
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Myelitis, Transverse / diagnostic imaging
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Myelitis, Transverse / etiology
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Myelitis, Transverse / immunology*
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Myelitis, Transverse / virology
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Spinal Cord / diagnostic imaging
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Spinal Cord / immunology*
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Spinal Cord / virology
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Zika Virus / pathogenicity*
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Zika Virus / physiology
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Zika Virus Infection / complications
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Zika Virus Infection / diagnostic imaging
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Zika Virus Infection / immunology*
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Zika Virus Infection / virology
Substances
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Autoantibodies
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Contrast Media
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MOG protein, human
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Myelin-Oligodendrocyte Glycoprotein
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Gadolinium