Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

Tatsuya Nishihara; Satoshi Kuno; Hiroshi Nonaka; Sho Tabata; Natsumi Saito; Shinji Fukuda; Masaru Tomita; Shinsuke Sando; Tomoyoshi Soga

doi:10.1039/c8cc06068a

Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

Chem Commun (Camb). 2018 Oct 16;54(83):11745-11748. doi: 10.1039/c8cc06068a.

Authors

Tatsuya Nishihara¹, Satoshi Kuno, Hiroshi Nonaka, Sho Tabata, Natsumi Saito, Shinji Fukuda, Masaru Tomita, Shinsuke Sando, Tomoyoshi Soga

Affiliation

¹ Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, Japan. nishi-t@ttck.keio.ac.jp soga@sfc.keio.ac.jp.

PMID: 30276401
DOI: 10.1039/c8cc06068a

Abstract

Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

MeSH terms

Acetaminophen / analogs & derivatives*
Acetaminophen / metabolism
Animals
Antigens, Neoplasm / analysis*
Antigens, Neoplasm / metabolism
Biomarkers, Tumor / analysis
Biomarkers, Tumor / metabolism
Cell Line, Tumor
Humans
Mice
Neoplasms / diagnosis*
Neoplasms / metabolism
Staining and Labeling / methods
beta-Galactosidase / metabolism*

Substances

Antigens, Neoplasm
Biomarkers, Tumor
Acetaminophen
beta-Galactosidase