Gene Function Discovery for Kinetoplastid Pathogens

Reza Salavati; Vahid H Gazestani

doi:10.1016/j.pt.2018.09.003

Gene Function Discovery for Kinetoplastid Pathogens

Trends Parasitol. 2019 Jan;35(1):8-12. doi: 10.1016/j.pt.2018.09.003. Epub 2018 Sep 28.

Authors

Reza Salavati¹, Vahid H Gazestani²

Affiliations

¹ Institute of Parasitology, McGill University, 21111 Lakeshore Road, Ste. Anne de Bellevue, Montreal, Quebec H9X3V9, Canada; McGill Centre for Bioinformatics, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec H3G0B1, Canada; Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Montreal, Quebec H3G1Y6, Canada. Electronic address: reza.salavati@mcgill.ca.
² Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.

PMID: 30274697
DOI: 10.1016/j.pt.2018.09.003

Abstract

We propose to integrate the existing and new experimental data with computational tools to model interaction networks for the most prominent kinetoplastid pathogens. These interaction networks will vastly expand the functional annotation of the kinetoplastid genomes, which in turn are critical for identifying new routes of disease intervention.

Keywords: genome annotation; kinetoplastids.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Computational Biology*
DNA, Kinetoplast / genetics
Euglenozoa Infections / parasitology*
Euglenozoa Infections / prevention & control
Genetic Association Studies
Genome, Protozoan / genetics*
Humans
Kinetoplastida / genetics*
Kinetoplastida / physiology
Protein Interaction Maps / genetics

Substances

DNA, Kinetoplast