Evaluation of biocompatible monomers as substitutes for TEGDMA in resin-based dental composites

Mater Sci Eng C Mater Biol Appl. 2018 Dec 1:93:80-87. doi: 10.1016/j.msec.2018.07.059. Epub 2018 Jul 23.

Abstract

This works reports the synthesis and characterization of diallyl(5-(hydroxymethyl)-1,3-phenylene) dicarbonate (HMFBA) and 5-(hydroxymethyl)-1,3-phenylene bis(2-methylacrylate) (HMFBM) monomers and its evaluation as Bis-GMA eluents in the formulation of composite resins for dental use. The experimental materials formulated with HMFBA and HMFBM monomers presented flexural strength values similar to those of the control group formulated with Bis-GMA/TEGDMA. Regarding volumetric contraction percentage, the values obtained of experimental materials with HMFBA was 1.88% and for HMFBM was 4.15%, both lower than control resin (4.68%). In the case of double bond conversion, the resin formulated with HMFBA monomer exhibited a greater degree of conversion (87%). Besides, the DMA analyses proved that the values for Tg guarantee a good mechanical performance at body temperature. The new resins formulated with HMFBA and HMFBM monomers exhibit a cellular viability close to 100%, which indicates the absence of cytotoxicity towards fibroblastic cells.

Keywords: Biomaterials; Composites; MMA crosslinking; Photopolymerization.

MeSH terms

  • Animals
  • Cell Line
  • Composite Resins* / chemistry
  • Composite Resins* / pharmacology
  • Drug Evaluation, Preclinical
  • Fibroblasts / cytology
  • Fibroblasts / metabolism*
  • Materials Testing*
  • Mice
  • Polyethylene Glycols* / chemistry
  • Polyethylene Glycols* / pharmacology
  • Polymethacrylic Acids* / chemistry
  • Polymethacrylic Acids* / pharmacology

Substances

  • Composite Resins
  • Polymethacrylic Acids
  • triethylene glycol dimethacrylate
  • Polyethylene Glycols