This article is a literature review to determine the state of the science regarding the impact of nursing interventions in the treatment of hepatitis C. Hepatitis C is a chronic disease impacting millions of people globally. Treatment is currently available that has the potential to cure the disease. Medication adherence is vital to the eradication of the disease. Nursing interventions could possibly assist in the improvement in medication adherence. By reviewing the literature, the factors influencing patient outcomes were identified. Four themes identified in the literature are influence of comorbidities, self-motivation, psychological factors, and provider support. The research studies are compared and contrasted within and across the themes. Identification of what is known and what is not known about nursing interventions in the treatment of hepatitis C is illustrated in the conclusion of the article. Finally, suggestions for future research are presented. Specific areas of study are identified for focus in the future research.