Synthesis of O-1- O-6 Substituted Positional Isomers of d-Glucose-Thioether Ligands and Their Ruthenium Polypyridyl Conjugates

Lucien N Lameijer; Julien le Roy; Stefan van der Vorm; Sylvestre Bonnet

doi:10.1021/acs.joc.8b01342

Synthesis of O-1- O-6 Substituted Positional Isomers of d-Glucose-Thioether Ligands and Their Ruthenium Polypyridyl Conjugates

J Org Chem. 2018 Nov 2;83(21):12985-12997. doi: 10.1021/acs.joc.8b01342. Epub 2018 Oct 23.

Authors

Lucien N Lameijer¹, Julien le Roy¹, Stefan van der Vorm¹, Sylvestre Bonnet¹

Affiliation

¹ Leiden Institute of Chemistry , Leiden University, Gorlaeus Laboratories , P.O. Box 9502, Leiden 2300 RA , The Netherlands.

Abstract

A library of positional isomers of d-glucose ( O-1- O-6) as ligands and their 11 light-active ruthenium conjugates has been synthesized. A protecting group strategy without the necessity of using palladium on carbon for the modification for the 2- O and 4- O position allows for the incorporation of sulfur donor atoms as ligands for transition metal complexes.

Publication types

Research Support, Non-U.S. Gov't