Surfactant Components and Tracheal Aspirate Inflammatory Markers in Preterm Infants with Respiratory Distress Syndrome

Giovanna Verlato; Manuela Simonato; Sonia Giambelluca; Margherita Fantinato; Alessio Correani; Maria Elena Cavicchiolo; Elena Priante; Virgilio Carnielli; Paola Cogo

doi:10.1016/j.jpeds.2018.08.019

Surfactant Components and Tracheal Aspirate Inflammatory Markers in Preterm Infants with Respiratory Distress Syndrome

J Pediatr. 2018 Dec:203:442-446. doi: 10.1016/j.jpeds.2018.08.019. Epub 2018 Sep 27.

Authors

Giovanna Verlato¹, Manuela Simonato², Sonia Giambelluca³, Margherita Fantinato¹, Alessio Correani⁴, Maria Elena Cavicchiolo¹, Elena Priante¹, Virgilio Carnielli⁴, Paola Cogo⁵

Affiliations

¹ Neonatal Intensive Care Unit, Department of Women's and Children's Health, University Hospital of Padova, Padova, Italy.
² Pediatric Research Foundation Institute "Città della Speranza", Padova, Italy; Division of Pediatrics, Department of Medicine, University of Udine, Udine, Italy.
³ Department of Women's and Children's Health, University of Padova, Padova, Italy.
⁴ Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
⁵ Division of Pediatrics, Department of Medicine, University of Udine, Udine, Italy.

PMID: 30270169
DOI: 10.1016/j.jpeds.2018.08.019

Abstract

In 93 preterm infants ≤32 weeks of gestational age and 12 control infants, epithelial lining fluid disaturated-phosphatidylcholine, surfactant protein A and B, albumin, and myeloperoxidase activity were assessed after intubation and before exogenous surfactant administration. We found that disaturated-phosphatidylcholine, surfactant protein B, and myeloperoxidase were significantly higher in preterms with chorioamnionitis.

Keywords: chorioamnionitis; disaturated-phosphatidylcholine; preterm newborns; surfactant; surfactant proteins.

MeSH terms

Albumins / metabolism
Chorioamnionitis / metabolism
Epithelium / pathology
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Inflammation / metabolism*
Peroxidase / metabolism
Phosphatidylcholines / metabolism
Pregnancy
Prospective Studies
Pulmonary Surfactant-Associated Protein A / metabolism
Pulmonary Surfactants / therapeutic use
Respiratory Distress Syndrome, Newborn / drug therapy*
Respiratory Distress Syndrome, Newborn / metabolism*
Surface-Active Agents / therapeutic use*
Trachea / metabolism*

Substances

Albumins
Phosphatidylcholines
Pulmonary Surfactant-Associated Protein A
Pulmonary Surfactants
Surface-Active Agents
Peroxidase