Long non-coding RNA HULC affects the proliferation, apoptosis, migration, and invasion of mesenchymal stem cells

Exp Biol Med (Maywood). 2018 Sep;243(13):1074-1082. doi: 10.1177/1535370218804781. Epub 2018 Sep 30.

Abstract

Exploring the molecular mechanisms of growth and function in MSCs is the key to improve their clinical therapeutic effects. Currently, more and more evidence show that the long non-coding RNA (lncRNA) plays an important role in the growth, stemness and function of MSCs.Both HULC and MALAT1 are the earliest discovered LNCRNAs, which are closely related to tumor growth. All of them can promote the growth of liver cancer stem cells. Previously, we have studied the effects of MALAT1 on the growth and function of MSCs. In this study, we focused on the effects of HULC on MSCs. We elucidated the effects of HULC on the growth and differentiation of MSCs, and explored the relationship between inflammatory stimuli and HULC expression in MSCs. Our findings provide a new molecular target for the growth and clinical application of MSCs.

Keywords: Mesenchymal stem cells; cell apoptosis; cell proliferation; highly upregulated in liver cancer; inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / physiology*
  • Cell Differentiation / physiology
  • Cell Line, Tumor
  • Cell Movement / physiology*
  • Cell Proliferation / physiology*
  • Gene Expression Regulation, Neoplastic / genetics*
  • Humans
  • Mesenchymal Stem Cells / cytology*
  • Neoplastic Stem Cells / classification
  • RNA, Long Noncoding / genetics*

Substances

  • RNA, Long Noncoding