Diabetes, Depression, and Cognition: a Recursive Cycle of Cognitive Dysfunction and Glycemic Dysregulation

Curr Diab Rep. 2018 Sep 28;18(11):118. doi: 10.1007/s11892-018-1079-0.

Abstract

Purpose of review: The study aims to examine the effects of diabetes and depression on executive functioning (EF) and to review the effects of EF deficits on diabetes management.

Recent findings: Both type 2 diabetes and depression influence EF, and in turn, EF has an impact on diabetes management. Individuals with both comorbidities (i.e., diabetes and depression) experience greater deficits in EF than individuals with just one of the morbidities (i.e., depression or diabetes). The disruption in EF results in poor diabetes management and poor emotion regulation which ultimately increases the probability of a recursive cycle of depression and hyperglycemia. This recursive cycle can ultimately lead to diabetes-related complications.

Keywords: Depression; Diabetes; Executive processing; Memory.

Publication types

  • Review

MeSH terms

  • Blood Glucose / metabolism*
  • Cognition*
  • Cognitive Dysfunction / etiology*
  • Depression / etiology*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Diabetes Mellitus, Type 2 / psychology*
  • Executive Function
  • Humans

Substances

  • Blood Glucose