Data mining of micrornas in breast carcinogenesis which may be a potential target for cancer prevention

Jin-Wook Kang; Min-Ji Kim; Hyun-Ah Baek; Jeong-Sang Lee

doi:10.1007/s10068-016-0111-x

Data mining of micrornas in breast carcinogenesis which may be a potential target for cancer prevention

Food Sci Biotechnol. 2016 Mar 31;25(Suppl 1):143-151. doi: 10.1007/s10068-016-0111-x. eCollection 2016.

Authors

Jin-Wook Kang^{1

2}, Min-Ji Kim^{1

2}, Hyun-Ah Baek³, Jeong-Sang Lee^{1

2

3}

Affiliations

¹ 1Molecular Mechanisms of Functional Foods Laboratory, Jeonju University, Jeonju, Jeonbuk, 55069 Korea.
² 2Department of Functional Food and Biotechnology, College of Medical Science, Jeonju University, Jeonju, Jeonbuk, 55069 Korea.
³ 3Food Industry Research Institute, Jeonju University, Jeonju, Jeonbuk, 55069 Korea.

Abstract

The microRNAs (miRNAs) negatively regulate the stability and translation of target messenger RNAs by selectively binding. It has been implicated in diverse processes such as cellular differentiation, cell-cycle control, apoptosis, and carcinogenesis. Examination of tumor-specific miRNA expression profiles has revealed wide spread dysregulation of these molecules in diverse cancers. The available genomic bulk evidences were extracted from The Cancer Genome Atlas by using IluminaGA_miRNASeq platform in human breast cancer samples. After mining collected data, group of each miRNA ID was analyzed through five D/Bs (mirWalk, miranda, mirDB, RNA22, and TargetScan) on predicted and validated miRNA targets. Oncogenes known to have a high correlation with breast cancer (C-myc, HER2, cyclin D-1, N-RAS, FGF-4, FGF-3, BRCA1, and BRCA2) are subject in this study to select their relevant miRNAs. Function of miRNA regulation will be essential to achieve a complete understanding of carcinogenesis and these miRNAs would be potential target for breast cancer prevention.

Keywords: breast cancer; chemoprevention; data mining; microRNA; target.