Effect of defatted pepper (Capsicum annuum L.) seed extracts on high-fat diet-induced obesity in C57BL/6J mice

Jeehye Sung; Jinwoo Yang; Younghwa Kim; Myunghee Kim; Heon Sang Jeong; Junsoo Lee

doi:10.1007/s10068-016-0226-0

Effect of defatted pepper (Capsicum annuum L.) seed extracts on high-fat diet-induced obesity in C57BL/6J mice

Food Sci Biotechnol. 2016 Oct 31;25(5):1457-1461. doi: 10.1007/s10068-016-0226-0. eCollection 2016.

Authors

Jeehye Sung¹, Jinwoo Yang¹, Younghwa Kim², Myunghee Kim³, Heon Sang Jeong¹, Junsoo Lee¹

Affiliations

¹ 1Division of Food and Animal Sciences, Chungbuk National University, Cheongju, Chungbuk, 28644 Korea.
² 2School of Food Biotechnology and Nutrition, Kyungsung University, Busan, 48434 Korea.
³ 3Department Food Science and Technology, Yeungnam University, Gyeongsan, Gyeongbuk, 38541 Korea.

Abstract

This study investigated the effect of defatted pepper seed ethanolic extract (DPSE) on high-fat diet-induced obesity in C57BL/6J mice. The mice were fed a normal diet (ND), high fat diet (HFD), or HFD in combination with DPSE (100 and 200mg/kg body weight) for 7 weeks. Supplementing the HFD of mice with DPSE significantly decreased body weight gain and food efficiency ratio induced by HFD. The amount of epididymal fat and size of adipocytes were also dramatically reduced by DPSE supplementation. Although no statistical significance was found between the HFD and HFD plus DPSE groups in plasma fat deposition, liver weight, and hepatic cholesterol contents were significantly reduced in the DPSE-treated group. In conclusion, these results suggest that DPSE could prevent obesity and adiposity. These effects may be important in developing therapeutic agents against obesity in future.

Keywords: epididymal fat; high-fat diet; mice; obesity; pepper seed.