The solubility of drugs is a crucial physicochemical property in the drug discovery or development process and for improving the bioavailability of drugs. There are various methods for evaluating the solubility of drugs including manual measurement methods, mathematical methods, and smart methods. Manual measurement and mathematical methods have some defects which make the smart systems more reliable and important in this field. In this review, various instruments used for the solubility determination, along with the smart systems, have been discussed. Mechanism and applications of each method have been elaborated in detail. Moreover, unique characteristics as well as some limitations of discussed methods are also described.
Keywords: Smart systems; drugs; solubility.