Correlation of vitamin D binding protein gene polymorphism and protein levels in chronic obstructive pulmonary disease compared with non-chronic obstructive pulmonary disease subjects

Benjamas Chuaychoo; Rungsunn Tungtrongchitr; Wantanee Kriengsinyos; Siriporn Tuntipopipat; Nattira On-Nom; Chaowanee Chupeerach

doi:10.2217/pme-2018-0005

Correlation of vitamin D binding protein gene polymorphism and protein levels in chronic obstructive pulmonary disease compared with non-chronic obstructive pulmonary disease subjects

Per Med. 2018 Sep;15(5):371-379. doi: 10.2217/pme-2018-0005. Epub 2018 Sep 27.

Authors

Benjamas Chuaychoo¹, Rungsunn Tungtrongchitr², Wantanee Kriengsinyos³, Siriporn Tuntipopipat³, Nattira On-Nom³, Chaowanee Chupeerach³

Affiliations

¹ Department of Medicine, Division of Respiratory Disease & Tuberculosis Siriraj Hospital, Mahidol University, 2 Pranok Road, Bangkok Noi, Bangkok 10700, Thailand.
² Department of Tropical Nutrition & Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok 10400, Thailand.
³ Institute of Nutrition, Mahidol University, 999 Phutthamonthon 4 Rd., Salaya, Phutthamonthon, Nakhon Pathom 73170, Thailand.

PMID: 30259785
DOI: 10.2217/pme-2018-0005

Abstract

Aim: The risk of vitamin D binding protein (DBP) variations in chronic obstructive pulmonary disease (COPD) compared with non-COPD Thai males were investigated.

Materials & methods: The rs7041 and rs4588 polymorphisms of the DBP gene and protein level were measured in 136 COPD and 68 non-COPD Thai males.

Results: In the COPD group, GC1-1 gave increased forced expiratory volume at 1 s % predicted compared with GC1-2 but with no significant difference. Significantly lower average DBP serum levels were observed in COPD than non-COPD subjects. Positive correlation between serum DBP and forced expiratory volume at 1 s % predicted was observed in non-COPD subjects.

Discussion & conclusion: DBP variations might be associated with risk factors in COPD caused by both inflammatory and vitamin D circulation processes.

Keywords: COPD; lung function; macrophage activating factor; single nucleotide polymorphism; vitamin D binding protein.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Case-Control Studies
Forced Expiratory Volume / genetics
Forced Expiratory Volume / physiology
Genetic Predisposition to Disease / genetics
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics
Pulmonary Disease, Chronic Obstructive / genetics*
Pulmonary Disease, Chronic Obstructive / metabolism
Respiratory Function Tests
Risk Factors
Severity of Illness Index
Thailand
Transcriptome / genetics
Vitamin D / metabolism
Vitamin D-Binding Protein / blood
Vitamin D-Binding Protein / genetics*
Vitamin D-Binding Protein / metabolism

Substances

GC protein, human
Vitamin D-Binding Protein
Vitamin D