As a type of novel noncoding RNAs, circular RNAs (circRNAs) have attracted great interest due to its different characteristics from linear RNAs. They are abundantly and stably present in the transcriptome of eukaryotic cells, with development stage specificity and high conservatism. Because circRNAs are not easily degraded by exonuclease RNase R, they can exist more stably in body fluids than linear RNAs. Based on these unique conditions, circRNAs have great potential value as clinical diagnostic and prognostic markers. As the research deepens, more and more evidences suggest that circRNAs may be closely associated with many diseases, especially cancer. Numerous studies have demonstrated the abnormal expression of circRNAs in cancer, and they can regulate the occurrence and progression of cancer by targeting key genes. Abundant circRNAs in tissues and cells can be released into saliva and blood. It is undeniable that circRNAs are a class of promising future biomarkers for cancer diagnosis and prognosis. Here we summarize the researches on circRNAs and cancer over the past few years. We expect this summary to be a stepping stone to further exploration of possible circRNAs as cancer biomarkers.
Keywords: Biomarkers; Cancer; Circular RNAs (circRNAs); Diagnosis; Prognosis.