Circular RNAs as Novel Biomarkers for Cardiovascular Diseases

Qiulian Zhou; Zhongrong Zhang; Yihua Bei; Guoping Li; Tianhui Wang

doi:10.1007/978-981-13-1426-1_13

Circular RNAs as Novel Biomarkers for Cardiovascular Diseases

Adv Exp Med Biol. 2018:1087:159-170. doi: 10.1007/978-981-13-1426-1_13.

Authors

Qiulian Zhou^{1

2

3}, Zhongrong Zhang^{2

3}, Yihua Bei^{2

3}, Guoping Li⁴, Tianhui Wang^{5

6}

Affiliations

¹ Shanghai Applied Radiation Institute, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China.
² Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China.
³ Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, China.
⁴ Cardiovascular Division of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China. wangth@shu.edu.cn.
⁶ Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, China. wangth@shu.edu.cn.

PMID: 30259365
DOI: 10.1007/978-981-13-1426-1_13

Abstract

Cardiovascular diseases are among the most serious diseases, which are a leading cause of death across the world. Early diagnosis and prognosis prediction are keys for treatment and reduction of death rates. Circular RNAs (circRNAs) play a critical role in the physiology and pathology of biological system and participate in the development of diseases. In addition, circRNAs are relative stable and abundant. Therefore, many studies have suggested that circRNAs could be used as biomarkers for diseases, such as neurological diseases, cancers, immune diseases, and digestive diseases. Here we summarize recent studies on circRNAs and compare the characteristics of circRNAs with traditional biomarkers. Finally, we highlight the value of circRNAs as potential biomarkers for cardiovascular diseases, including acute myocardial infarction, heart failure, coronary artery disease, and hypertension. In conclusion, circRNAs may be promising biomarkers for cardiovascular diseases.

Keywords: Biomarkers; Cardiovascular diseases; Circular RNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers / analysis
Cardiovascular Diseases / diagnosis*
Cardiovascular Diseases / genetics
Forecasting
Humans
RNA / analysis*
RNA / genetics
RNA / metabolism
RNA, Circular
RNA, Long Noncoding / analysis
RNA, Long Noncoding / metabolism

Substances

Biomarkers
RNA, Circular
RNA, Long Noncoding
RNA