Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1

J Virol. 2018 Nov 27;92(24):e00709-18. doi: 10.1128/JVI.00709-18. Print 2018 Dec 15.

Abstract

Interferons limit viral replication by inducing intracellular restriction factors, such as the GTPase MxB (also designated MX2), which inhibits HIV-1 and, as recently shown, herpesviruses. Inhibition of these viruses occurs at ill-defined steps after viral entry and requires formation of MxB dimers or oligomers, but GTP hydrolysis is needed only for blocking herpesviruses. Together with previous findings on related MxA, the new research on MxB highlights the mechanistic diversity by which MX proteins interfere with viral replication.

Keywords: HIV-1; MX2; MxB; herpesviruses; interferons.

Publication types

  • Review

MeSH terms

  • HIV-1 / drug effects
  • HIV-1 / physiology*
  • Herpesviridae / drug effects
  • Herpesviridae / physiology*
  • Humans
  • Interferons / pharmacology*
  • Models, Molecular
  • Myxovirus Resistance Proteins / chemistry
  • Myxovirus Resistance Proteins / metabolism*
  • Protein Conformation
  • Protein Multimerization
  • Up-Regulation
  • Virus Internalization / drug effects
  • Virus Replication / drug effects

Substances

  • MX2 protein, human
  • Myxovirus Resistance Proteins
  • Interferons