Biocatalytic synthesis of lactones and lactams

Abstract

Cyclic esters and amides (lactones and lactams) are important active ingredients and polymer building blocks. In recent years, numerous biocatalytic methods for their preparation have been developed including enzymatic and chemoenzymatic Baeyer-Villiger oxidations, oxidative lactonisation of diols, and reductive lactonisation and lactamisation of ketoesters. The current state of the art of these methods is reviewed.

Keywords: Baeyer-Villiger oxidation; biocatalysis; lactams; lactones; oxidative Lactonisation.