Linear IGA Dermatosis

Excerpt

Linear IgA bullous dermatosis (LABD), also known as linear IgA dermatosis or linear IgA disease, is a relatively rare subepidermal vesiculobullous disease that can occur in both adults and children. In children, the disease is known as "chronic bullous disease of childhood" and tends to have a distinct clinical appearance, but the underlying pathogenesis of the disease remains the same. In the adult form of the disease, a drug-induced etiology must be thoroughly considered. Genetic predisposition may also be partially responsible for the development of the chronic bullous disease of childhood or LABD, and several human leukocyte antigen (HLA) types have been implicated as portending an increased risk of disease development. HLA-B8, HLA-DR3, HLA-DQ2, and HLA-cw7 are well known for their association with both the childhood and adult variants of LABD.