Endoscopic submucosal dissection (ESD) is an established and effective treatment modality for endoscopic resection of premalignant and early-stage malignant gastrointestinal lesions. Compared to endoscopic mucosal resection (EMR), ESD is generally associated with higher rates of en bloc, R0, and curative resections and lower rates of local recurrence. As in ESD the whole lesion is resected in one piece, it enables the best possible T-staging based on pathology assessment of the resected lesion. So far, there have been few reports of esophageal ESD in the West and none from Scandinavia. We aim to describe for the first time in Scandinavia, the implementation and results of ESD for the treatment of esophageal neoplasia, namely early esophageal squamous cell neoplasia (ESCN) and Barrett's esophageal neoplasia (BEN).