PSPC1 potentiates TGF-β-dependent metastatic dissemination

Hsi-Wen Yeh; Yuh-Shan Jou

doi:10.1080/23723556.2018.1472058

PSPC1 potentiates TGF-β-dependent metastatic dissemination

Mol Cell Oncol. 2018 Aug 1;5(4):e1472058. doi: 10.1080/23723556.2018.1472058. eCollection 2018.

Authors

Hsi-Wen Yeh¹, Yuh-Shan Jou¹

Affiliation

¹ Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Abstract

Metastatic reprogramming toward malignant tumor progression relies on the activation of oncogenic regulators, yet the cellular determinants remain elucidated. Through identification of aberrant prognostic cancer genes, we identified paraspeckle component 1 (PSPC1) functions as a master activator of metastatic reprogramming by activating epithelial-to-mesenchymal transition (EMT), stemness and TGF-β1 pro-metastatic switch.

Keywords: CSCs and TGF-β1 pro-metastatic reprogramming; EMT; PSPC1.

Grants and funding

This research was supported by Academia Sinica and Ministry of Science and Technology (MOST 107-0210-01-19-01) and by the MOST, Taiwan: (MOST 106-2321-B-001-051 and MOST104-2320-B-001-009MY3).