RIPK1-dependent mitophagy: A novel mechanism to eliminate cells detached from the extracellular matrix

Mark A Hawk; Zachary T Schafer

doi:10.1080/23723556.2018.1465015

RIPK1-dependent mitophagy: A novel mechanism to eliminate cells detached from the extracellular matrix

Mol Cell Oncol. 2018 May 10;5(4):e1465015. doi: 10.1080/23723556.2018.1465015. eCollection 2018.

Authors

Mark A Hawk¹, Zachary T Schafer¹

Affiliation

¹ Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.

Abstract

For cancer cells to survive during extracellular matrix (ECM)-detachment, they must inhibit anoikis and rectify metabolic deficiencies that lead to the induction of non-apoptotic cell death. Here, we highlight and discuss our recent study implicating receptor-interacting protein kinase-1 (RIPK1) in the induction of mitophagy, the production of reactive oxygen species (ROS) and the consequent elimination of ECM-detached cells.

Keywords: RIPK1; cell death; mitophagy; reactive oxygen species; signal transduction.

Grants and funding

Z.T. Schafer is supported by a Research Scholar Grant from the American Cancer Society (RSG-14-145-01), a Career Catalyst Grant from Susan G. Komen (CCR14302768), a grant from Phi Beta Psi Sorority, and funds from the Coleman Foundation. M.A. Hawk is supported by a GRFP award from the National Science Foundation.