The NF-κB pathway regulates cell physiology under stress conditions. We have recently described a novel NF-κB regulatory mechanism, by which SIRT6 induces cysteine monoubiquitination of the methyltransferase SUV39H1. This causes SUV39H1 dissociation from the gene encoding the NF-κB inhibitor IκBα, increasing its expression and leading to NF-κB pathway inactivation.
Keywords: IκBα; NF-κB; SIRT6; SKP2; SUV39H1; Sirtuins, NAD+.