The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth

Jeongkyu Kim; Philipp Oberdoerffer; Simran Khurana

doi:10.1080/23723556.2018.1441629

The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth

Mol Cell Oncol. 2018 Apr 4;5(3):e1441629. doi: 10.1080/23723556.2018.1441629. eCollection 2018.

Authors

Jeongkyu Kim¹, Philipp Oberdoerffer¹, Simran Khurana²

Affiliations

¹ Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD, USA.
² National Institute for Allergy and infectious Diseases, NIH, Bethesda, MD, USA.

Abstract

The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-modulated macroH2A1 chromatin organization for cell function and malignant transformation.

Grants and funding

This work was supported by the Intramural Research Program of the National Institutes of Health (NIH), NCI, Center for Cancer Research. The authors declare no competing interests.