In Vivo Efficacy of Ellagic Acid against Candida albicans in a Drosophila melanogaster Infection Model

Antimicrob Agents Chemother. 2018 Nov 26;62(12):e01716-18. doi: 10.1128/AAC.01716-18. Print 2018 Dec.

Abstract

The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a Drosophila melanogaster model. Candida albicans bacteria were inoculated into Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of EA against fungal infection in Drosophila melanogaster was observed at nontoxic concentrations. This study showed that EA is a promising tool for the treatment of candidiasis.

Keywords: Candida albicans; Drosophila melanogaster; candidiasis; ellagic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology*
  • Candida albicans / drug effects*
  • Candida albicans / growth & development
  • Candida albicans / pathogenicity
  • Candidiasis / drug therapy
  • Candidiasis / immunology
  • Candidiasis / microbiology
  • Disease Models, Animal
  • Drosophila melanogaster / drug effects*
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / immunology
  • Drosophila melanogaster / microbiology
  • Ellagic Acid / pharmacology*
  • Female
  • Gene Expression
  • Heterozygote
  • Longevity / immunology
  • Toll-Like Receptors / genetics
  • Toll-Like Receptors / immunology*

Substances

  • Antifungal Agents
  • Toll-Like Receptors
  • Ellagic Acid