Neonatal fever: A puzzling case

Arch Pediatr. 2018 Oct;25(7):435-438. doi: 10.1016/j.arcped.2018.08.004. Epub 2018 Sep 21.

Abstract

Toxoplasmosis is a potentially serious fetal infection associated with maternal seroconversion of toxoplasmosis during pregnancy. Follow-up and treatment vary between different countries. We present a case of congenital toxoplasmosis with unusual physiopathology and symptomatology. The mother was immunized before the beginning of pregnancy but immunosuppressive treatments for Crohn disease maintained during the pregnancy could explain toxoplasmosis reactivation in the mother and congenital toxoplasmosis. The baby presented reversible B lymphopenia and hypogammaglobulinemia.

Keywords: Congenital toxoplasmosis; Lymphopenia; Neonatal fever.

Publication types

  • Case Reports

MeSH terms

  • Agammaglobulinemia / etiology
  • Anti-Infective Agents / therapeutic use
  • Female
  • Fever / etiology
  • Humans
  • Immunization
  • Immunosuppressive Agents / adverse effects*
  • Infant, Newborn
  • Infant, Newborn, Diseases / diagnosis
  • Lymphopenia / etiology
  • Pregnancy
  • Pregnancy Complications, Infectious / etiology*
  • Toxoplasmosis, Congenital / diagnosis*

Substances

  • Anti-Infective Agents
  • Immunosuppressive Agents