Endovascular Treatment for Venous Sinus Stenosis in Idiopathic Intracranial Hypertension: An Observational Study of Clinical Indications, Surgical Technique, and Long-Term Outcomes

World Neurosurg. 2019 Jan:121:e165-e171. doi: 10.1016/j.wneu.2018.09.070. Epub 2018 Sep 21.

Abstract

Background: Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure. IIH causes significant morbidity marked by incapacitating headaches and visual disturbances. This study investigated the long-term outcomes of venous sinus stenting in a large group of patients with IIH.

Methods: We retrospectively reviewed all patients at our institution who underwent venous sinus stenting for IIH over 6 years (July 1, 2012-June 30, 2018). A particular focus was dedicated to collecting demographic, clinical, radiologic, and outcomes data. All patients had failed medical management.

Results: Of the 110 patients evaluated for IIH, 42 underwent venous sinus stenting, with a mean follow-up of 25.6 months (range, 8.7-60.7 months). The mean age was 32 years (range, 15-52 years), 38 (90%) were women, and the mean body mass index was 35.6 kg/m2 (range, 18.6-47.5 kg/m2). Prior to the stenting procedure, all patients had headaches, visual disturbances, and papilledema. Of the 39 patients who had an ophthalmologic evaluation poststenting, 29 (74%) had resolution of their papilledema. Eighteen patients (43%) had complete resolution of their headaches after the stenting procedure, whereas 22 patients (52%) remained under a neurologist's care for chronic migraine and other types of headaches. Two patients underwent a restenting procedure for disease progression, and 1 patient experienced an in-stent thrombosis.

Conclusions: A multidisciplinary approach involving neurosurgeons, ophthalmologists, radiologists, and neurologists is integral in the management of patients with IIH to prevent the complications of papilledema. Venous sinus stenting offers a safe and effective means of treating IIH.

Keywords: Endovascular; Idiopathic intracranial hypertension; Neurosurgery; Pseudotumor cerebri; Stent; Venous sinus stenosis.

Publication types

  • Observational Study

MeSH terms

  • Adolescent
  • Adult
  • Chronic Disease
  • Constriction, Pathologic / surgery
  • Cranial Sinuses / surgery*
  • Endovascular Procedures / instrumentation
  • Endovascular Procedures / methods
  • Female
  • Graft Occlusion, Vascular / etiology
  • Humans
  • Male
  • Middle Aged
  • Migraine Disorders / etiology
  • Migraine Disorders / surgery
  • Neurosurgical Procedures / methods
  • Papilledema / etiology
  • Papilledema / surgery*
  • Patient Care Team
  • Pseudotumor Cerebri / complications*
  • Reoperation
  • Retrospective Studies
  • Stents
  • Treatment Outcome
  • Young Adult