Gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide signaling in adipose tissue

J Diabetes Investig. 2019 Jan;10(1):3-5. doi: 10.1111/jdi.12942. Epub 2018 Oct 22.

Abstract

GIPR signaling in adipose tissue plays an important role in HFD-induced insulin resistance and hepatic steatosis in vivo, with no direct effect on fat accumulation, through IL-6 signaling.

Publication types

  • Editorial

MeSH terms

  • Adipose Tissue / metabolism*
  • Animals
  • Diabetes Mellitus, Type 2 / metabolism*
  • Gastric Inhibitory Polypeptide / metabolism*
  • Humans
  • Insulin Resistance
  • Mice, Knockout
  • Obesity / metabolism*
  • Receptors, Gastrointestinal Hormone / genetics
  • Receptors, Gastrointestinal Hormone / metabolism*
  • Signal Transduction

Substances

  • Receptors, Gastrointestinal Hormone
  • Gastric Inhibitory Polypeptide
  • gastric inhibitory polypeptide receptor