Aim: The β-CD-LPC molecule was synthesized based on the conjugation of LPC and β-CD molecules and it could self-assemble into liposome which was used to encapsulate the Dox to form nanomedicine for the cancer therapy.
Materials & methods: The anticancer and antitumor effect of β-CD-LPC-Dox nanomedicine was studied with the vitro and vivo experimental methods.
Results: The result showed that β-CD-LPC liposome had high Dox drug-loading rate and a good sustained-release effect. Cell experiment showed that the β-CD-LPC-Dox nanomedicine could effectively induce cancer cell apoptosis and in vivo experiments showed that β-CD-LPC-Dox liposome could effectively inhibit tumor growth and had an effective anticancer activity with lower biotoxicity.
Conclusion: The β-CD-LPC-Dox nanomedicine could be applied as a candidate drug to therapy the cancer.
Keywords: Dox; anticancer; antitumor; drug delivery system; drug-loading rate; drug-release behavior; liposome; phospholipids; β-CD; β-CD-LPC-Dox.