Simplified and automatable radiochemical separation strategy for the production of radiopharmaceutical quality 86Y using single column extraction chromatography

Eduardo Aluicio-Sarduy; Reinier Hernandez; Hector F Valdovinos; Christopher J Kutyreff; Paul A Ellison; Todd E Barnhart; Robert J Nickles; Jonathan W Engle

doi:10.1016/j.apradiso.2018.09.016

Simplified and automatable radiochemical separation strategy for the production of radiopharmaceutical quality ⁸⁶Y using single column extraction chromatography

Appl Radiat Isot. 2018 Dec:142:28-31. doi: 10.1016/j.apradiso.2018.09.016. Epub 2018 Sep 14.

Authors

Eduardo Aluicio-Sarduy¹, Reinier Hernandez², Hector F Valdovinos¹, Christopher J Kutyreff¹, Paul A Ellison¹, Todd E Barnhart¹, Robert J Nickles¹, Jonathan W Engle³

Affiliations

¹ Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.
² Department of Radiology, University of Wisconsin-Madison, Madison, WI 53705, USA.
³ Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Radiology, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: jwengle@wisc.edu.

PMID: 30245439
DOI: 10.1016/j.apradiso.2018.09.016

Abstract

We present a simplified, automatable single-column radiochemical separation method using the extraction chromatographic branched-DGA resin for the production of no-carrier-added ⁸⁶Y with a radiochemical yield higher than 95%, an apparent molar activity of 1.4 ± 0.4 Ci/μmol (DOTA) and 2.3 ± 0.7 Ci/μmol (DTPA), and a run-to-run recycling efficiency of the isotopically-enriched target of 98 ± 1%. These results enable the preparation of ⁸⁶Y radiopharmaceuticals for ⁸⁶Y/⁹⁰Y-based cancer theranostic applications.

Keywords: PET; Radionuclide production; Single column extraction chromatography; Theranostic; Y-86.