Progress in studies of necroptosis and its relationship to disease processes

Zhen Wang; Li-Min Guo; Shu-Chao Wang; Dan Chen; Jie Yan; Feng-Xia Liu; Ju-Fang Huang; Kun Xiong

doi:10.1016/j.prp.2018.09.002

Progress in studies of necroptosis and its relationship to disease processes

Pathol Res Pract. 2018 Nov;214(11):1749-1757. doi: 10.1016/j.prp.2018.09.002. Epub 2018 Sep 15.

Authors

Zhen Wang¹, Li-Min Guo², Shu-Chao Wang², Dan Chen², Jie Yan³, Feng-Xia Liu⁴, Ju-Fang Huang⁵, Kun Xiong⁶

Affiliations

¹ Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China.
² Department of Neurobiology and Human Anatomy, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
³ Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
⁴ Department of Human Anatomy, School of Basic Medical Science, Xinjiang Medical University, Urumqi, Xinjiang, 830011, China.
⁵ Department of Neurobiology and Human Anatomy, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China. Electronic address: huangjufang@csu.edu.cn.
⁶ Department of Neurobiology and Human Anatomy, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China. Electronic address: xiongkun2001@163.com.

PMID: 30244947
DOI: 10.1016/j.prp.2018.09.002

Abstract

This review briefly introduces the mechanism and detection methods of necroptosis in recent years. The most significant points of this review focus on the involvement of necroptotic proteins in disease progression. The following aspects are summarized: 1) RIPs, MLKL, and the upstream and downstream molecules that mediate necroptosis; 2) The development of detection methods for necroptosis; 3) The involvement of related necroptotic proteins in diverse diseases etiology; and 4) The application of necroptotic proteins in disease diagnosis.

Keywords: Disease processes; MLKL; Necroptosis; Necroptotic proteins; RIPs.

Publication types

Review

MeSH terms

Animals
Cell Death / physiology*
Humans