The Bioimaging Applications of Mesoporous Silica Nanoparticles

Feby Wijaya Pratiwi; Chiung Wen Kuo; Si-Han Wu; Yi-Ping Chen; Chung Yuan Mou; Peilin Chen

doi:10.1016/bs.enz.2018.07.006

The Bioimaging Applications of Mesoporous Silica Nanoparticles

Enzymes. 2018:43:123-153. doi: 10.1016/bs.enz.2018.07.006. Epub 2018 Sep 10.

Authors

Feby Wijaya Pratiwi¹, Chiung Wen Kuo², Si-Han Wu³, Yi-Ping Chen³, Chung Yuan Mou⁴, Peilin Chen⁵

Affiliations

¹ Nanoscience and Technology Program, Taiwan International Graduate Program, Taipei, Taiwan; Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan; Department of Chemistry, National Taiwan University, Taipei, Taiwan.
² Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.
³ Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, Taiwan.
⁴ Department of Chemistry, National Taiwan University, Taipei, Taiwan.
⁵ Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: peilin@gate.sinica.edu.tw.

PMID: 30244805
DOI: 10.1016/bs.enz.2018.07.006

Abstract

The unique features of Mesoporous Silica Nanoparticles (MSNs) provide a suitable platform to carry fluorescence dyes for various bioimaging applications. Several strategies have been developed to conjugate a variety of dyes either in the pores or on the surfaces of MSNs to form the fluorescence MSNs (FMSNs). In this chapter, we will discuss recent research progress and future development of FMSNs for living system imaging. We will first describe different strategies for the fabrications of FMSNs. Then, we will discuss the recent developments of cellular and intracellular imaging including self-probe for the interactions of FMSNs with the cells, receptor and organelle labeling, sensing and tracking of biological system, and monitoring the drug delivery and release processes. Moreover, we will include the applications of FMSNs as contrast agents for in vivo imaging. Finally, we will conclude and highlight the challenges and opportunities for MSNs in medical applications.

Keywords: Bioimaging; Mesoporous silica nanoparticles; Nanomedicine; Surface modification; Targeted delivery; Theranostics.

Publication types

Review

MeSH terms

Contrast Media / administration & dosage
Contrast Media / chemistry
Drug Delivery Systems*
Fluorescent Dyes / administration & dosage*
Fluorescent Dyes / analysis
Humans
Molecular Imaging / methods*
Nanoparticles / administration & dosage*
Nanoparticles / chemistry
Porosity
Silicon Dioxide / administration & dosage*
Silicon Dioxide / chemistry

Substances

Contrast Media
Fluorescent Dyes
Silicon Dioxide